hips:?314 Chip: 1.2M wells?316 Chip: 6.1M wells?318 Chip: 11M wellsРRothberg J.M. et al Nature doi:10.1038/nature10242РSensor PlateРSilicon SubstrateРDrainРSourceРBulkРdNTPР∆ pHР∆ QР∆ VРSensing LayerРH+Р6Р4种dNTP依次流过Ion芯片?DNA 聚合反应产生的氢离子的直接检测?每个碱基的检测只需要几秒Р扩展性高?CMOS(互补金属氧化物半导体) 技术?40 年的摩尔定律Р简单?天然dNTP?无激光光源?非光学检测?无拍照系统?非荧光检测?非酶级联放大检测Р速度快?快速完成测序反应Р7Р芯片就是测序仪РSmall GenomeРTranscriptomeР100MР1GР10GРSequence Output per RunР100GРExomeРSmall to Large Gene PanelsР10MРUnprecedented Scalability ?10,000-Fold From Ion 314™ to Ion PIII™ ChipРIon 316™РIon 314РIon 318™РIon PII™РHuman GenomeРIon PI™РIon PIII™РFrom 1.2 Million Sensors …………………to 1.2 Billion SensorsРThe content provided herein may relate to products that have not been officially released and is subject to change without noticeР10РIon技术平台在各研究领域应用
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