microenvironment,rowsandspreads.thecellularenvironmentinwhichthetumorexists,includingsurroundingbloodvessels,immunecells,fibroblasts,othercells,signalingmolecules,andtheextracellularmatrix.-------维基百科全书-------美国NCI定义The“seedandsoil”eptedalthoughthe“seed”maynowbeidentifiedasaprogenitorcell,initiatingcell,cancerstemcell(CSC),ell,andthe“soil”discussedasahostfactor,stroma,niche,anmicroenvironment种子和土壤的衍生肿瘤的六大特征炎症成为肿瘤的新标志之一Nature2009自给自足生长信号(Self-SufficiencyinGrowthSignals)抗生长信号的不敏感(InsensitivitytoAntigrowthSignals)细胞死亡抵抗(ResistingCellDeath)潜力无限的复制能力(LimitlessReplicativePotential)持续的血管生成(SustainedAngiogenesis)组织浸润和转移(TissueInvasionandMetastasis)避免免疫攻击(AvoidingImmuneDestruction)促肿瘤的炎症(TumorPromotionInflammation)细胞能量异常(DeregulatingCellularEnergetics);基因组不稳定和突变(GenomeInstabilityandMutation)肿瘤的十大特征
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