th cerebral ischemia ?lose their ability to autoregulateРAutoregulatory failureРCerebral Blood FlowРAdapted with permission from Varon J, Marik PE. Chest. 2000;118:214-227.РMAP (mm Hg)РICP/CPP ManagementР150Р125Р100Р75Р50Р25Р0Р0Р25Р50Р75РCerebral Perfusion Pressure (mm Hg)РCerebral Blood Flow? (mL/100 g/min)РZone of NormalРAutoregulationРMaximumРConstrictionРMaximumРDilatationРPassiveРCollapseР0Р25Р50РICP (mm Hg)РICP = intracranial pressure; CPP = cerebral perfusion pressure.РVasodilatory Cascade ZoneРAutoregulation Breakthrough ZoneРGOALРICP/CPP ManagementР150Р100Р75Р25Р0Р0Р25Р50Р75РCerebral Perfusion Pressure (mm Hg)РCerebral Blood Flow? (mL/100 g/min)РZone of NormalРAutoregulationРPassiveРCollapseР0Р25Р50РICP (mm Hg)РICP = intracranial pressure; CPP = cerebral perfusion pressure.Р125Р50