gap junction channels in the nervous system are connexin proteins, and, as recently identified, pannexin proteins. ?More than 20 connexin genes have been found in the mouse and human genome. ?Several are strongly expressed in astrocytes (Cx26, Cx30, Cx43) and oligodendrocytes (Cx29, Cx32, Cx47) ,but most are not expressed in neurons ?Cx36, is expressed widely in the brain. Data from freeze-fracture replica immunolabeling indicate that Cx36 protein appears in neuron-neuron gap junctions but not in gap junctions between astrocytes and/or oligodendrocytes.?In the adult brain, neurons form gap junctions with other neurons, but not with astrocytes. However, there is some evidence for significant neuron-glia coupling in a few brain regions.РElectrical synapses in retinal ON cone bipolar cells
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