糖尿病降脂PPT幻灯片

Haffner SM et al. N Engl J Med. 1998;339:229-234.РIncidence (%)Р3.5Р18.8Р20.2Р45.0РP<0.001РP<0.001Р无糖尿病Р糖尿病Рn = 1304Рn = 69Рn = 890Рn = 169Р0Р10Р20Р30Р40Р50Р无糖尿病,无心梗?n = 1304Р心梗无糖尿病?n = 69Р糖尿病无心梗?n = 890Р糖尿病合并心梗?n = 169Р糖尿病是冠心病的等危症Р糖尿病心脏介人预后较非糖尿病差Р0Р5Р10Р15Р20Р25Р30Р35РNo diabetesРDiabetesР5-year mortality (%)РCABGРPTCAРAdapted from BARI Investigators. N Engl J Med 1996:335:217–225Р心梗及微血管终点与血糖关系РUpdated mean hemoglobin A1C concentration (%)РStratton IM, et al. BMJ. 2000;321:405-412.Р每 1000 人年校正后事件数(%)Р心梗?微血管终点Р80?60?40?20?0Р5?6?7?8?9?10?11Р随访时间( 月)Р主要大血管事件累计发病率(%)Р25Р20Р15Р10Р5Р0Р标准治疗组Р强化治疗组Р0Р6Р12Р18Р24Р30Р36Р42Р48Р54Р60Р66Р∆ 6%Р95% CI: 0.94 -1.16, ?P=0.32Р强化降糖对主要大血管事件的影响? ADVANCEРADVANCE Collaborative Group. N Engl J Med. 2008;358:2560-72.Р大血管事件:心血管疾病死亡,非致死性心肌梗塞或中风Р第4年出现下降趋势?(HbA1C:6.7%)