less effective against atypical mycobacterial species.РIsonizidРicsРAbsorbtion: Isoniazid is readily absorbed from the gastrointestinal tract. A 300-mg oral dose (5 mg/kg in children) achieves peak plasma concentrations of 3–5 μg/mL within 1–2 hours. ?Distribution: Isoniazid diffuses readily into all body fluids and tissues. ?Metabolism:? Liver N-acetyltransferase(N乙酰转移酶)?rapid acetylators -- hepatitis?slow acetylators-- Peripheral neuropathy?Excretion: The products of metabolism are excreted mainly in the urine.РIsonizidРIsoniazidРIsoniazidР4. Clinical Uses:РCombination with rifampicin,or second-line antituberculous agents, isoniazid is used for severe infections with tubercle bacilli.?As a single agent,isoniazid is indicated for prevent and treatment of mild tuberculosis of early stage.
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