新生儿听力及基因联合筛查_图文

age-Hearing Association http:// /public/hearing/Congenital-Hearing-Loss/ 新生儿听力缺失分类- 部位分类 sensorineural hearing loss 感音神经性听力缺失耳蜗和或听神经通路缺陷 conductive hearing loss 传导性听力缺失外耳和或中耳的声音传导障碍 mixed type 混合型 A fourth category : auditory neuropathy spectrum disorder ( ANSD ) 听神经病谱系障碍占儿科永久性听力缺失的 8%-12% ic causes , 50% Non-ic causes :先天性感染,高胆红素血症,耳毒性药物最常见 Handb Clin Neurol , 2013, 113:1527-1538. Paediatr Child Health, 2011, 16(5): 301-305. 70% 为非综合征听力缺失,多数与耳蜗毛细胞功能障碍有关 30% 为综合征听力缺失 Risk factors for neonatal sensorineural hearing loss ?永久性听力缺失的家族史?颅面畸形,包括外耳畸形?先天性感染,包括细菌性脑膜炎、 CMV 感染,弓形虫,风疹病毒,疱疹病毒,梅毒? Physical findings consistent with an underlying syndrome associated with hearing loss ? NICU 住院>2 天,或不论住院时间长短,有以下任何一项者:体外膜式氧合;辅助通气;使用耳毒性药物;达到换血指征的高胆红素血症。 Paediatr Child Health, 2011, 16(5): 301-305.