类风湿关节炎-----幻灯片

roup 4比group 1 and 2功能改善早且明显,?三个月?groups 1 and 2 D-HAQ1.0 , groups 3 and 4 0.6 (P < 0.001). ?一年? groups 1 and 2 D-HAQ 0.7 in groups 3 and 4 0.5 (P = 0.009). ?total Sharp/Van der Heijde radiographic joint score were 2.0, 2.5, 1.0, and 0.5 in groups 1-4, respectively (P < 0.001). ?There were no significant differences in the number of adverse events and withdrawals between the groups.Р联合治疗РFIN-RACo trial (芬兰Rheumatoid bination Therapy trial).159例,5年,早期控制疾病活动是改善远期关节功能的关键? Arthritis Rheum2005(1)?荷兰TEMPO study 682例应用methotrexate, etanercept, 或二者的联合有预后不良指标者早期应用生物制剂延缓骨侵蚀,即使停药仍能保持疗效? Arthritis Rheum2005(1)Р联合治疗Р加拿大the METGO study? 对 MTX反映欠佳, 加用肌注金制剂? Arthritis Rheum. 2005 MayР联合治疗РCSA + MTX最好,无统计学差异? Italy早期类风湿105例(CSA + MTX n = 34, CSA + HCQ n = 35) or CSA alone (n = 36)l联合治疗, Rheumatol Int.25(1)