低频率电刺激外侧苍白球对大鼠癫痫治疗作用及相关机制地研究

genucleus.ircuitwhichisbelievedtoparticipateinseizurepropagation.Besides,regionalatrophyinthebilateralglobuspalliduswerefoundinidiopathicgeneralizedepilepsy.Furthermore,eurons.ThereforeGPemightbeapromisingtargetofDBSforinterfering、析tllepilepsy.SowefirstinvestigatetheeffectsofLFSandHFStargetingtheGPeonseizuresgeneratedbyamygdaloidkindling,maximalelectroshock(MES)andamygdaloid-kindledseizures.ThemechanismsunderlyingDBStreatmentforepilepsyremainunclear.EEGbackgroundactivityisoneoftheimportantmarkersfordiagnosisofneuropsychiatricdisorders.EEGofepilepticpatientstendtohavemoreobviouschanges.Somespecialchangesmaybeauraofepilepsy.Previousstudiesfoundthatthe6rhythm(delta,0.5-4Hz)、0rhythm(theta,4-8Hz)andYrhythm(gamma,30-100Hz)haractersinepilepsy.Thus,wesupposeDBSGPemayplaydifferentrolesbyintervingⅥI