d to the damage to the function of the intestinal barrier and bacterial translocation induced by hypoxic conditions. Damage of intestinal ultra microstructure、down-regulated of TJ protein Occludin and the large release mediators of inflammation may participate in the pathological process. The TLR4-mediated transcellular transfer of bacteria is probably involved in it. 4. The damage to intestinal mucosa barrier function and bacterial translocation was significantly alleviated after blockage of the TLR4/NF-κB signaling pathway by PDTC. This result suggested that TLR4/NF-κB signaling pathway is an effective intervention targets for treatment of intestinal injury in high altitude. Key words: Hypoxia; Toll-like receptor4; NF-κB; Intestinal mucosa barrier; Bacterial translocation; Tight junction
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