lymphocytes intheairway;the bronichial lining ciliatedcelldamaged ornecrosis and the epithelial necrosis and fallsoff;the goblet cellsincreased and secrets a large number of mucus;smooth muscle hypertrophy,bronchial wall thickening and thickening ofbasement membrane.Recent study showed thattheasthma is not only a purely inflammatory disease.but alsoisassociated with structuralremodeling ofthe airway characterized byairway epithelialdamage,wall thickening,and subepithelial fibrosis.The remodeling oftheairway istheprincipal factorthatleads toairway hyperresponsiveness and the reversible airflow obstruction.The asthma ismore prevalence ininner—citypopulations.It hasbeen suggested thatthereis astrong link between allergen exposure and sensitization and development ofasthma.In particular, 万方数据
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