oin﹑diosgenin and harides, That may be because sauting with bran cause allantoin and harides easier for dissolving out by making medicine loose,and cause diosgenin content rise by making steroid saponin hydrolyzed,this finding can offer a new direction for further approach to processing principle.Through the orthogonal design combined with multi-index test,we fristly choose the optimal processing craft of Dioscoreae Rhizoma,during the verified test,showed the soften-cut and stir-frying with bran process technology is feasibility and stability.we establish quality standard and HPLC fingerprint of of Dioscoreae Rhizomawhich can use to control their quality.Keywords:Dioscoreae Rhizoma;Processing technology;orthogonal test;quality standard;fingerprint.