nGK,EdfeldtK(2005).“Tolltobepaidatthegatewaytothevesselwall’’.Arterioscler.Thromb.Vasc.Bio1.25(6):1085—7.2ZhangZ,LouboutinJP,WeinerDJ,eta1.HumanairwayepithelialcellssensePseudomonasaeruginosainfectionviarecognitionofflagellinbyToll—likereceptor5.InfectIm—man.2005.73:7151—60.3AdamoRSokolS,SoongG,eta1.PseudomonasaeruginosaflagelhactivateairwayepithelialcellsthroughasialoGM1andmll——likereceptor2aswellastoll——likereceptor5.AmJRespirCellMolBiol,20o4,30:627.34.4VermaA,AroraSK,KuraviSK,eta1.RolesofspecificaminoacidsintheNterminusofPseudomonasaeruginosaflageHinandofflagellinglycosylationintheinnateimmuneresponse.InfectImmun,2005,73:8237—46.5RamphalRBalloyV,HuerreM,eta1.TLR2and4arenotinvolvedinhypersusceptibilitytoacutePseudomonasaerug—inosalunginfections.JImmuno1.2005.175:3927—34.(收稿日期:2012—03—13)