信号通路对抗?LPS 诱导的РHUVECs细胞起到重要的作用。磷酸肌酸可以通过稳定细胞整体能量Р代谢、 ATP 合成酶和线粒体肌酸激酶( CKmt),尤其是对细胞线粒体Р呼吸链 FAD途径的显著影响来对抗?LPS诱导的 HUVECs细胞凋亡,提Р示磷酸肌酸可能通过保护内皮细胞功能对动脉粥样硬化或其他验证Р相关的心血管疾病起到治疗作用。РOur present study strongly suggests that PCr plays a vital role inРLPS-induced HUVECsthrough mitochondrial oxidative phosphorylationРsignaling pathway. PCr improves creatine shuttle of HUVECsthroughРdirectly enhanced ATP synthase and mitochondrial creatine kinase, andРreactived FADH2pathway in mitochondrial respiration chain. Our workРprovides new insight for the noval antiapoptotic effects of PCr inРendothelial cells, which may give a pharmacological basis for the clinicalРapplication?of?PCr for?treatment?of?atherosclerosis or?otherРinflammationrelated?cardiovascular diseases which?is?related?toРendothelial cell apoptosis.
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