n (HE) staining. Results: Compared with model control group, Scr, BUN, GAS and MTL decreased while SS increased significantly in every administra- tion group. The levels of Scr, BUN, GAS and MTL in the high Chaibanliuhe decoction group were lower than that in the low Chaibanliuhe decoction group and Niaoduqing control group while the level of SS was higher. Compared with that in the Niaoduqing control group, GAS and MTL decreased while SS increased in the low Chaibanliuhe decoction group. There was no significant difference between low Chaibanliuhe decoction group and Niaoduqing control group with the levels of Scr and BUN. Conclusion: Chaibanliuhe decoction can improve the gastrointestinal symptoms of CRF in rat model by decreasing the levels of GAS and MTL and increasing the level of SS.