flow, as a result of the user in the content of the cargo handling, time and service level put forward higher request, in order to meet the requirements of users well, must be continuously optimized distribution center operation method. Distribution center in the logistics system adjustment and the buffer role, solve the contradictions of rhythm or batch of supply and demand imbalance. In this paper, according to the distribution center distribution operation status quo from the work optimization, distribution operation optimization, and distribution route optimization, analyze the logistics distribution operations research, thus reduce social costs, improve prehensive utilization of resources and the social efficiency.РKeywords: logisticsdistribution centeroperation optimizationefficiency