341 21.593 20.943 15.480 15.219 13.268 附表 3. 家兔静脉注射 PSP 后不同时间 lnC 值肾损组正常组组别 25 10 15 20 25组别 25 10 15 20 25 1 3.349 3.137 3.108 3.042 3.114 2.984 2 2.652 2.670 2.576 2.504 2.403 2.291 3 4 3.581 3.494 3.428 3.411 3.381 3.349 5 6 3.066 2.764 2.697 2.585 2.679 2.643 7 3.713 3.279 3.228 3.125 2.909 3.153 8 3.506 3.433 3.420 3.293 3.293 3.054 9 3.458 3.349 3.363 3.207 3.288 3.345 10 3.536 3.072 3.042 2.740 2.723 2.585 附表 4.正常家兔和肾功能受损家兔的药动学参数肾损组正常组组别 K C0 T1/2 VD CL 组别 K C0 T1/2 VD CL 1 0.0114 26.267 60.7895 0.1142 0.0013 2 0.0164 15.2793 42.2561 0.1963 0.0032 3 4 0.0090 35.0158 77.0000 0.0857 0.0008 5 6 0.0142 18.5728 48.8028 0.1615 0.0023 7 0.0232 34.2090 29.8707 0.0877 0.0020 8 0.0170 34.8760 40.7647 0.0860 0.0015 9 0.0052 30.0001 133.2692 0.1000 0.0005 10 0.0361 30.3380 19.1967 0.0989 0.0036
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