高截留分子量超滤膜在临床中的应用

OLUTE SIZEРDEFINITION:The cut-off point of a solute for any membrane is a sieving coefficient of 0.1 . This means that 10% of the molecules will pass and 90% will not pass .Р0.5Р60 ureaРCut-off pointРO.1Р筛选系数与截留分子量РSolute Classes by Molecular WeightРDaltonsР• Inflammatory Mediators (1,200-50,000)Р“small”Р“middle”Р“large”Р高截留分子量超滤膜РRR-AB-34 Jan 2011РNew functional membrane with defined larger pore sizeРHCO membraneР< 0,01 µmР< 0,02 µmР~ 0,09 µmР~ 0,30 µmР: pore diameterРhigh fluxРhigh cut-off*Рprotein separation membraneРplasma separation membraneРVariation of membrane pore sizeРElectron micrographs of inner membrane surfaceРsieving coefficientР100Р1000Р10000Р100000Р1000000Р0Р0.2Р0.4Р0.6Р0.8Р1РMolecular weight [D]РClassical Filter?30 kDРhuman kidneyРhigh cut-offРHigh Cut-Off Hemofilter