ion? Patient, parasite carrier?Route of transmission ?female mosquito biting person?blood transfusion?Susceptibility:?universal susceptibility?no-cross-immunity?re-infection?Epidemic features: ?sporadic or endemic, tropic or subtropicРPathogenesisРMechanism of attack? merozoite? RBC rupture malaria pigment? products of metabolism? ? blood stream allergyРP. Faciparam: produce microvascular disease?magnitude of the parasitemia & age of patient?no specific Ab or cell -mediated responseРPathologyРAnemia:?P. Vivax - retiform RBC?P. Malariae - mature RBC?P. Falciparum - every RBC?Prolifeation of mononuclear phagocyte?hepatomegaly?splenomegaly?Cerebral edema & congestionРClinical manifestationРIncubation period: ? quartan malaria: 24-30 day? tertian malaria: 13~15 day? malignant malaria: 7~12 day
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