AIDS抗病毒治疗的依从性

可以促进依从性和治疗结果Р直视下的服药方法(DOT) 与自我管理的服药方法(SAT)РFischl M et al. 8th CROI; 2001, Chicago, IL.РDOT <400?SAT <400Р达到检测不到HIV RNA的病人%?HIV RNA < 400 copies/mlР依从性与治疗成功的关系Р81Р64Р50Р25Р6Р0Р25Р50Р75Р100Р>95%Р90%-95%Р80%-90%Р70%-80%Р<70%РMean adherence rateРPatients Reaching Undetectable HIV RNA LOQ 400 (%)РP = .00001Р1Paterson. Ann Intern Med 2000;133:21.РGreatest danger zone for developing resistanceРData from the “IDV era” demonstrates??the impact of even minor variations in adherence ? 95% adherence is required for optimal virologic suppressionР依从性与病毒学治疗失败的关系РMEMS = Medication Events Monitoring SystemРPaterson DL et al. Ann Intern Med 2000;133:21–30.Р•?结果显示当依从性95%时可以达到最佳的病毒抑制,而且即使在依从性上有很小的变化也会对病毒学治疗结果产生明显的负面影响Р22Р55Р67Р71Р82Р0Р25Р50Р75Р100Р 95%Р90%-94.9%Р80%-89.9%Р70%-79.9%Р<70%Р病毒学治疗失败的病人%Р依从性, %