ionРregulation of cell growth and differentiation?regulation of cell function?oxygen sensing ?activation of redox-sensitive transcription factors?activation of redox-sensitive second messenger systemsРWhere and why are reactive oxygen species generated?РMitochondria? by-product of the oxidative metabolism?Phagocyte NADPH oxidase ? microbial killing?NADPH oxidase of non-phagocytic cells ?cell growth, cell signalingРThe NOX family of NADPH oxidasesРReview: Lambeth et al. Novel homologs of gp91phox.Trends in Biochemical Sciences 25: 459-461, 2000.Рgp91phox ?homologyРEF-handsРNox1?colon?Nox2?phagocytes?Nox3?inner ear?Nox4?kidneyРNox5 testis and lymphoid tissuesРO2РO2-РNADPHРe-РStructure of the NAD(P)H oxidaseРCharacteristics of neutrophil and vascular NAD(P)H oxidaseРNAD(P)H Oxidase Activation
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