第?一?作?者?讲?坛?|?|?发?现?的?历?程РConformational Transition of? Amyloid b-peptide?PNAS, 2005, 102, 5403-5407Р许叶春?导师:蒋华良研究员А沈建华研究员Р蛋白质功能的实现? ——动态结构模拟Р老年痴呆的致病机理和治疗策略Р老年斑Р神经微丝缠结РTrends cell Biol. 1998, 8,447-453РAlzheimer’s Disease (AD)Р老年痴呆的致病机理和治疗策略РCholinergic HypothesisРJ. Pharmacol. Exp. Ther. 2003,306,821-827Р老年痴呆的致病机理和治疗策略РAmyloid HypothesisР老年痴呆的致病机理和治疗策略РDrugsРTacrineРDonepezilРRivastigmineРGalanthamineРHuperzine AР石杉碱甲和乙酰胆碱酯酶的结合与解离Рlower toxicity, higher selectivity, and longer time inhibitionРHuperzine AР石杉Р石杉碱甲和乙酰胆碱酯酶的结合与解离
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