α硫辛酸临床应用精要

349-371 / 例如:研究表明,当硫辛酸与砷的摩尔比为 8∶1时,可以完全防止小鼠砷中毒。硫辛酸与金属离子螯合机制 Ref : Hong YS, Jacobia SJ, Packer L, Patel MS. The inhibitory effects of pounds on mammalian pyruvate plex and its ponents. Free Radic Biol Med. (1999) 26(5-6) 685-94. / 修复受损细胞硫辛酸不仅对长时间的氧化损伤有较强抵抗作用,而且对 VC 和 VE 不能修复的、较严重的细胞氧化损伤也可进行有效修复。并且由于硫辛酸具有脂溶性,二氢硫辛酸具有水溶性,二者结合可以深入到细胞中的各个部位而起作用,而只具有脂溶性或水溶性的抗氧化剂却没有这一功能。硫辛酸药理机制——高效抗氧化剂(3) Ref : Jordan SW, Cronan JE Jr. (1997). "A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate plex in Escherichia coli and mitochondria.". J Biol Chem. 272 (29): 17903 – 6. Cronan JE, Zhao X, Jiang Y. (2005). "Function, attachment and synthesis of lipoic acid in Escherichia coli.". Adv Microb Physiol. 50: 103 – 46.