reduced, and the higher modulation order of the system, the more sensitive to ICI. Thenclassical method to suppress ICI, ICI Self-Cancellation (ICI-SC), ICISelf-Cancellationis studied and simulated,though MATLAB simulation to test its performance.Finally, design the structure of frame and transceiverin OFDM system based on GNU Radio and USRP, elaboratedsignal flow processing module of sending end and 中南民族大学硕士学位论文IIIreceiving end.Meanwhile these blocks were connected with Python language. And then, themodule of ICI Self-Cancellation wasdesigned with the soft language of C++. Finally the testing environment and results of systemswill be given.KeyWords: Orthogonal Frequency Division Multiplexing(OFDM); Inter-Carrier Interference; ICISelf-Cancellation;GNURadio