ed that 0sampleshad mutations omsMe therange of our syStem while 8samples had fullyconcordant result.The specificity of our method was thus 00%pared with sequencing. Inchapter 3,we firstgave abriefintroduction ofpharmacogenomics by usillg warfarin and clopidogrel asexamples.We then described the establishment of atwo -reaction,four—color MMCA assay thatcould detect 8com.rnon SNPs useful for administration ofwarfarin and clopidogrel.As low as50pg/reaction genomic DNA Can bed嗽ted reliably.This MMCA assay was thenused toanalyze 27samples andthefi-equencies of8SNPs were calculated.Weconcluded thatthisnew method 3 Abswaa could provide arapid,accurate,sensitive toolforwarfarin and clopidogrel interms of pharmacogenomics Key words:mukicolor meking curve analysis;G6PD deficiency;pharmacogenomics 4
全文预览
