in bone marrow cells; for details on the technique, see for example, Krishna and Hayashi (2000).3.1 Preliminary analysesSince the main roleofthe in vivomicronucleus assay in regulatory schemes is that of confirming (or disproving) the positive in vitroresults, it is of interest to check how the in vivomicronucleus results relate to the rodent carcinogenicity data and to the primaryin vitroprediction test, i.e., the Salmonella typhimurium(Ames) test. Tables I and II display the relationships between the in vivomicronucleus ad the two reference tests. The results for rodent carcinogenicity and the Ames test were retrieved from the freely available ISSCAN v3a database,7which is characterized by: 5.nlm.nih.gov/cgi-bin/sis/search6duct_info.php?products_id=777p/dati/cont.php?id=233&lang=1&tipo=7
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