ope.we observed the change of cell skeleton.The results show that TGF—beta can induce the assemble of cytoskeleton and the formation of pseudopodia.After treated with graphene oxide,the number of pseudopodia in 4T 1 cells was reduced.РGraphene oxide also Can also inhibit TGF—beta-induced upregulafion on pseudopodiaРnumber in B16 cells.РTaken together,graphene oxide can cause a significantly influence on the metastasis of tumor cells.This work studied biological safety and cellular effects of the graphene oxide,and explored the molecular mechanisms of graphene oxideРIVР万方数据Р山东大学硕士学位论文Рinhibiting tumor cell migration.All these work findings revealed the potential application of nano-graphene oxide in cancer therapy.РKeywords:graphene oxide;tumor migration;metastasis;EMT:cell skeleton.РVР万方数据
全文预览
