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肿瘤分子靶向治疗

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ortof34patientswithclonalchromosomalabnormalitiesinPhiladelphia-negativecellsduringimatinibtreatmentofPhiladelphia-positivechronicmyeloidleukemia.Leukemia.2004Jun1025.CiardielloF,TortoraG.Anovelapproachinthetreatmentofcancer:targetingtheepidermalgrowthfactorreceptor[J].ClinCancerRes,2001,7(10):2958.26.CiardielloF,CaputoR,BiancoR,etal.InhibitionofgrowthfactorproductionandangiogenesisinhumancancercellsbyZD1839(Iressa),aselectiveepidermalgrowthfactorreceptortyrosinekinaseinhibitor[J].ClincancerRes,2001,7(5):145927. CohenMH,WilliamsGA,SridharaR,etal.FDAdrugapprovalsummary:gefitinib(ZD1839)(Iressa)tablets.Oncologist.2003;8(4):303-6.28. HainsworthJD,MainwaringMG,ThomasM,etal.Gefitinibinthetreatmentofadvanced,refractorynon-small-celllungcancer:resultsin124patients.ClinLungCancer.2003;4(6):347-55.

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