天然药物化学试题及答案

sh)346NaOMe261399AlCl3272426AlCl3/HCl260274357385NaOAc254400NaOAc/H3BO3256378(I)的1H-NMR(DMSO-d6,TMS)δppm:7.41(1H,d,J=8Hz),6.92(1H,dd,J=8Hz,3Hz),6.70(1H,d,J=3Hz),6.62(1H,d,J=2Hz),6.43(1H,d,J=2Hz),6.38(1H,s),5.05(1H,d,J=7Hz),其余略。(I)酸水解后检出D-葡萄糖和苷元,苷元的分子式为C15H10O6。FAB-MS示分子中含一分子葡萄糖。试回答下列各问:(1)该化合物为根据(2)是否有3-羟基根据(3)苷键构型为根据(4)是否有邻二羟基根据(5)写出(I)的结构式,并在结构上注明氢谱质子信号的归属。2.某化合物S为白色粉末,Liebermann-Burchard反应阳性,Molish反应阳性。其分子式为C42H66O14。酸水解检出甙元为齐墩果酸。糖为葡萄糖醛酸GlaUA及葡萄糖Glc(1:1)。碱水解检出葡萄糖。化合物S的13C-NMR化学位移值如下:化合物S甙元的13C-NMR数据化合物S糖部分13C-NMR化学位移值碳位齐墩果酸化合物SGlaUA138.339.8107.2228.027.074.4378.191.278.3439.740.475.8555.956.977.46 18.719.5172.4733.334.2Glc840.140.897.4948.249.074.21037.137.978.81123.624.371.112123.0124.179.513144.3145.262.81442.343.21528.429.31623.924.71747.248.41841.942.81946.447.42030.931.82134.235.0