activation. DiabetesMetab Res .2001;17: 448-458.4. Brownlee M, Vlassara H. Advanced protein glycosylation in diabetes and aging. Annu Rev Med .1995;46:223-234.5. Wautier JL, Zoukourian C, Chappey O, et al. . Receptor-mediated endothelial cell dysfunction indiabetic vasculopathy: soluble receptor for advanced glycation end products blocks hyperpermeabilityin diabetic rats. J Clin Invest. 1996; 97(1): 238-243.6. Xiao-Hua Guo, Qiao-Bing Huang, Bo Chen, Shu-yun Wang, Qiang Li, Yan-jun Zhu, Fan-Fan Hou,Ning Fu , Ming Zhao. Advanced glycation end products induce actin rearrangement and anization of F-actinAGERho GTPROCKERM ERM PMKK3/MKK6ERMp38 MAPKDisruptions of adhesion junction and tight junctionEndothelial barrier dysfunction and hyper-permeabilityReceptor mediated signalCell membraneRAGE? ?
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