entsnormalbonemassincreasednumberofremodelingsitesincreasedporosityofthebone,ietheremodelingspace,andthisgivesdecreasedbonemasBoneLoss:Cancellousvs.ountforlessthan25%ofthetotalbonemassinhealthyadults,itssurfaceareafarexceedsthatofcorticalbone.BoneLoss:Cancellousvs.CorticalBoneCancellousboneismoremetabolicallyactivethancorticalbone.esuncoupled,withosteoclasticactivityexceedingosteoblasticactivity,themassandstructuralintegrityofcancellousboneismoreseverelyaffectedthancorticalbone.BoneLoss:Cancellousvs.urringimmediatelypost-menopause,cancellousbonelossisincreased3-fold,whileratesofcorticalbonelossareslower.Therefore,urinareasrichincancellousbone(ie,thevertebraeandwrist),andBMDmeasurementshavefocusedonthesecriticalanatomicsiteshighturnoverwitheitherincreasedformationorincreasedresorptionorboth