系统生物学-基因组研究进展

plan to sequence the genomes of at least oneАthousand anonymous participants from a number ofАdifferent ethnic groups within the next three years,Аusing newly developed faster and less expensiveАsequencing technologies.? The project unites multidisciplinary research teamsАfrom institutes around the world, including Britain,АChina and the United States. Each will contribute toАthe enormous sequence dataset and to a refined humanАgenome map, which will be freely accessible throughАpublic databases to the munity and theАgeneral public alike.?/Р千人测序计划Р研究人员找出了1000多万个大大小小的基因变种,其中约800万个都是前所未知的。对于人群携带率在1%以上的基因变种,本次研究的覆盖率达到95%以上,得出了迄今最详尽的基因多态性图谱。这一成果在医学等领域有很高的应用价值,比如通过参照图谱,可以方便地找出致病的基因变种。?研究人员验证了在大型基因研究中综合使用多种基因测序手段的可行性。由于基因测序成本目前仍很高昂,如果能在“精测”一些基因序列的同时,对另一些基因序列只需“粗测”就能保证最终结果的准确性,将可以大幅降低基因测序研究的成本。