y ) ? InfectionРMechanisms of ?myocardial injuryРAcute myocardial injury ?(example: ischemia-reperfusion injury)Р(1) ATP deficiency ? (2) Calcium overload-induced hypercontraction? (3) Osmotic gradient and cell swelling? (4) Rapid generation of reactive oxygen species? (5) InflammationР(6) Opening of the mitochondrial permeability ? transition pore (mPTP)РJohansen JV, et al. Basic Res Cardiol, 100: 295 – 310 (2005)Р缺血和再灌注导致心肌细胞不可逆损伤的主要机制?(Ferdinandy P et al, 2007)Р2. Chronic myocardial injury (myocardial remodeling)Р心肌重塑:指在心肌损伤过程中,由于持续负荷过重及神经、体液过度激活,心肌组织在结构、功能、数量及基因表达等方面所发生的适应性变化。Р心肌缺血、心肌损伤、心肌重塑、心力衰竭之间形成恶性循环。Р心肌重塑的机制Р负荷过度Р神经体液过度激活Р蛋白激酶Р受体或力学感受器Р转录因子Р基因转录Р核Р心肌重塑Р原癌基因?生长因子?胶原与胶原酶?胎儿型蛋白?表达增加Р心肌损伤РNecrosis and apoptosis? myocardial remodelingРHeart failureРIschemiaР慢性心肌损伤恶性循环的形成Р二、心肌保护实验研究主要进展
全文预览
