*天花接种传入英国,后传入美国*Edward Jenner发现天花疫苗*Pasteur 发现狂犬病减毒疫苗(rabies attenuated ine)Variolation:parison of maximum and current morbidity for ine-preventable diseasesDiseaseMaximum casesYear1992Percentage change白喉Diphtheria麻疹Measles腮腺炎Mumps百日咳pertussis脊髓灰质炎Polio (paralytic)风疹RubellaCRS破伤风Tetanus乙型流感Heamophilusinfluenzae type B乙型肝炎Hepatitis B206,939694,134152,209265,269 21,269 57,686 20,000 1,560 20,000 26,6111921194119681934195219691964, 65192319841985 4 2,237 2,572 4,083 4 160 11 45 1,41216,12699.9999.7598.3198.4699.9899.7299.9597.1292.9439.400 10 100 1,000 10,000 100,000 1,000000 白喉Diphtheria1921风疹Rubella1969脊髓灰质炎Polio (paralytic)1952百日咳pertussis1934腮腺炎Mumps1968麻疹Measles1941报道的病例数Number of reported cases0 例美国报道的几种病在高峰年和1996年的病例数相比