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p55PIK在结直肠癌细胞增殖中的作用及转录后调控机制分析

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n cancer. J Clin Oncol. 2010; 28(6): 1075-1083. 6.Yuan TL, Cantley LC. PI3Ks pathway alterations in cancer: variations on a theme. Oncogene. 2008;27(41):5497-510. 7.Ritu Dhand, Kenta Hara, Lan Hiles, et al. PI3-kinase: structural and function analysis of intersubunit interactions. The EMBO Journal. 1994; 13(3): 511-521. 8.Vanhaesebroeck B, Guillermet GJ, Graupera M, et al. The emerging mechanisms of isoform-specific PI3Ks signalling. Nat Rev Mol Cell Biol. Nat Rev Mol Cell Biol.2010; 11(5):329-341. 9.Liu P, Cheng H, Roberts TMet al. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov.2009; 8(8):627-644. 10.Lievre A, Blons H, Laurent PP. Oncogenic mutations as predictive factors in colorectal cancer. Oncogene. 2010;29(21):3033-3043. 万方数据

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