最新人类载脂蛋白AⅤ与血脂和炎症因子的关系以及TNF-α下调其表达的机制初探-内科学心血管专业毕业论文

茎茎塑墨Р-l●——__●-_---___l●-●●-__________--●____--__l_--___-_-___--●____———————一一——РРРConclusionsРРRecombinated human Apo A V protein was expressed by prokaryotic expression system．2 McAbs were raised from mice·A double．antibodies sandwich ELISA for measuring recombinated humanРnpo AV was established．Human serum Apo AV level Was very low and negatively correlated with TG and BMI，but positively correlated with?HDL-C．Surem Apo AV Was negatively correlated with inflammatory cytokines Hs．CRP and TNF"Q．apo AV gene expression with protein production in HepG2 cell lines Was down。regulated byРTNF．Q and NF-r,B activation Was involved in the pathway．РРРРРKEY WORDS apolipoprotein A V，blood lipidinflammatoryРРРcytokincs，TNF-Q，expressionРРРРРРРРРРРРРРРРРРРРРРРРРРРРРIX