inglucocorticoid,omeprazole,inhibitorsuchasSSRIantidepressants,cimetidine,diltiazem,largeringlactone,nitroimidazoles,sedativehypnotics,verapamil,fluoroquinolone,classantihistamines)within30daysorduringthetrial;Subjectswhohavetakenanykindofdrugswithin14days;Subjectswhohavetakenparticipanttoanyotherclinicaltrialswithin30days;Subjectswhohavedonatedbloodorbeingtakensamplewithin3months;Bloodcoagulationdisordersorsubjectswhohavesubjectedtothromboembolismdisease;oproductduringthetrial;Subjectswhohaveafoodallergyorspecialdietaryrequirementsthatcan’epttheuniformdiets;Subjectswhohaveahistoryofmalignancy;Subjectswhohaveahistoryofmigraineorheadache;Subjectswhodrinktoomuchteaorcoffeeorotherkindsofbeveragecontainingcaffeine(morethan8cups);Subjectswhowasconsiderednotappropriateforthetrialbytheresearcher.