itch. j neurosci 2008; 28 (30):7659-7669. [3] lamotte rh, shimada sg, green bg and zelterman d pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage j neurophysiol march 2009 vol. 101 no. 3 1430-1443. [4] namer b, carr r, johanek lm, schmelz m, handwerker ho, ringkamp m. separate peripheral pathways for pruritus in man. j neurophysiol 2008; 100: 2062-2069. [5] papoiu a.d.p, coghill rc, kraft ra, wang h, yosipovitch g.a tale of two itches, common features and notable differences in brain activation evoked by cowhage andhistamine induced itch. neuroimage, 2011, article in press [6] reddy vb, iuga ao, shimada sg, lamotte rh, lerner ea. cowhage-evoked itch is mediated bya novel cysteine protease: a ligand of protease-activated receptors. j neurosci 2008; 28: 4331-4335.