iated apoptosis in cancer? ⅰ Tumour necrosis fact or receptors? ⅱ Bcl-2 family? ⅲ Other apoptotic modulators: cytochrome c, Apaf-1 and IAPs?Ⅱ Caspase-mediated autophagy in cancerРⅢ Targeted caspases and their substrates for drug discovery? ⅰ Caspase- 8, -9 and -3? ⅱ PARP -1 and Beclin-1Р1 Caspase-mediated apoptotic pathways in cancerР1.1 Tumour necrosis fact or receptorsРDuring this process, Fas ligand(FasL), which triggers trimerization of receptors and aggregation of intra-cellular death domains?(DDs) , leads to formation of a death- inducing plex (DISC ) . The death adaptor protein FADD?and photolytic enzyme caspase-8 are recruited to Fas.РThe Bcl-2 family is pivot al for regulation of apoptosis , and includes both anti- and pro-apoptotic proteins.Р1.2 Bcl-2 familyР1.2 Bcl-2 familyР截图 2
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