分子影像学简介小动物PETCT应用

内的磷酸化探针转录因子激活报告酶内源性蛋白PA.B.报告基因/基因表达的报告探针显像信号及信号的放大;分子特异性识别功能;体内分布和成像/治疗结果评价分子影像探针作用分子影像探针分类PET:18F、11C、124I、64Cu等标记小分子/多肽MRI:Gd-DTPA标记粒子,SPIO/USPIO光学:Cy5标记小分子/多肽超声:微泡和纳米微泡CT:碘标记粒子,碘油,低密度微泡PET-labeledProbesfor?BiologicalImaginghemodynamicparameters(H215O,15O-butanol,11CO,13NH3.....)substratemetabolism(18F-FDG,15O2,11C-palmiticacid....)proteinsynthesis(11C-leucine,11C-methionine,11C-tyrosine)enzymeactivity(11C-deprenyl,18F-deoxyuracil...)drugs(11C-cocaine,13N-cisplatin,18F-fluorouracil...)receptoraffinity(11C-raclopride,11C-carfentanil,11C-scopalamine)neurotransmitterbiochemistry(18F-fluorodopa,11C-ephedrine...)geneexpression(18F-penciclovir,18F-antisenseoligonucleotides...).....................................cyclotron11C,13N,15O,18FPETcandetectandimagesubnanomolarlevelsofthesetracersinvivo