on harides.1,2Р The pioneering work in 1890 by Fischer3 allowed him to determine the relativeРconfiguration and the synthesis of the most known aldohexoses. Based on theРassumption that in D-glyceraldehyde, the hydroxyl group was placed to the right,Рhe was able to propose correctly the structure of tetroses, pentoses, and aldohexosesР(Figure 1.3). The relative configuration of D-glyceraldehyde was later confirmedРby X-ray diffraction by Bijvoet in 1951. Consequently, all the resulting biologicallyРactive distereoisomeric aldoses derived from D-glyceraldehyde conserve alwaysРthe secondary alcohol next to the primary one to the right side in the FischerРprojection. Ketoses with three to six carbons are naturally produced from 1,3-РDihydroxyacetone, according to the tree shown in Figure 1.4.Р 1
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