核糖体的结构与功能研究——2009年诺贝尔化学奖简介

ineseAcademyofSciences,Beijing 100101,China)Р Abstract The2009NobelPrizeinChemistrywasawardedtoVenkatramanRamakrishnan,ThomasA.Steitz,Р andAdaE.Yonath"forstudiesofthestructureandfunctionoftheribosome".Theatomic-resolutionribosomeР structuressolvedbythelaureatesrevealedthestructuralbasisofthemechanismsofpeptidesynthesesbyribosome.Р Theydemystifiedseverallongstandingfunctionsofribosome,suchasthehighfidelityofthetranslationprocessР andthewobbleeffect.Theirworkalsopavedwaysforthedevelopmentofnewantibiotics,justwhenpublichealthР isfacedwithincreasingthreatfromdrug-resistantpathogenicbacteria.Р Keywords ribosome,crystallization,structure,functionР DOI: 10.3724/SP.J.1206.2009.00607Р *Correspondingauthor.Р Tel:86-10-64888548,E-mail:yonglin@ibp.Р Received:October15,2009 Accepted:October16,2009Р万方数据