gressionofccRCC,meanwhileclinicaldatawereusedforverification.Results TIMER2analysisРshowedthattheexpressionofSETD2wassignificantlydownregulatedinccRCCandrelatedtoimmuneinfiltration.РThemutationlandscapeofccRCCgeneshowedthatthefrequencyofSETD2mutationwas125%,rankingfourthРinsomaticmutationfrequency.AmongpatientswithccRCC,theprognosisintheSETD2highexpressiongroupwasРbetterthanthatintheSETD2lowexpressiongroup,andtheprognosisofpatientsinthehighimmuneinfiltrationРgroupwasbetterthanthatinthelowimmuneinfiltrationgroup.Conclusion HighexpressionofSETD2caninРcreasetheinfiltrationofimmunecellsanditskillingeffectontumorinccRCCpatients,thusplayingapositiveroleРintheprognosisofpatients.РKeywords SETD2;clearcellrenalcellcarcinoma;prognosis