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setd2在肾透明细胞癌中的表达及对患者预后的影响 胡庆庆

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gressionofccRCC,meanwhileclinicaldatawereusedforverification.Results  TIMER2analysisРshowedthattheexpressionofSETD2wassignificantlydownregulatedinccRCCandrelatedtoimmuneinfiltration.РThemutationlandscapeofccRCCgeneshowedthatthefrequencyofSETD2mutationwas125%,rankingfourthРinsomaticmutationfrequency.AmongpatientswithccRCC,theprognosisintheSETD2highexpressiongroupwasРbetterthanthatintheSETD2lowexpressiongroup,andtheprognosisofpatientsinthehighimmuneinfiltrationРgroupwasbetterthanthatinthelowimmuneinfiltrationgroup.Conclusion  HighexpressionofSETD2caninРcreasetheinfiltrationofimmunecellsanditskillingeffectontumorinccRCCpatients,thusplayingapositiveroleРintheprognosisofpatients.РKeywords SETD2;clearcellrenalcellcarcinoma;prognosis

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