T细胞免疫应答 T cell mediated immune response

TcellmediatedimmuneresponseI.Adaptiveimmuneresponse1.ImmuneresponseAgPlasmacellTCellmediatdimmunityBAbHumoralimmunityfeatures:specificity,memoryActivatedT2.ProcessofimmuneresponsestageofAgrecognitionstageofactivation,proliferationanddifferentiationeffectstageII.StageofAgrecognitionsiteofimmuneresponseAgBTAPC肽MHCMHCrestrictionImmunologicalsynapseIII.Stageofactivation,proliferationanddifferentiation1.ActivationofCD4+Tcell“Dual-signaltheory”T“1”“2”activation,proliferationdifferentiationeffectorcellmemorycell(clonalexpansion)2.SignaltransductionduringTcellactivationPTK 蛋白酪氨酸激酶 PLC-γ?磷酯酶C-γZAP-70 ζ链相关蛋白 PIP2?磷酯肌醇二磷酸SH2 Src同源区2 PKC?FAT 激活T的核因子AP-1 激活蛋白—1NF-κB B细胞κ链转录因子(核因子κB)MAPK 丝裂原激活的蛋白激酶GEF 鸟苷酸置换因子