n at the scientific meeting of the APMP of HongKONG. May 1999内部资料严禁翻印及传播1220位癌痛患者荟萃分析证实:多瑞吉?疗效优于口服缓释吗啡A J Clark, S.H.Ahmedzai,et al. Current Medical Research and Opinion 2004;20(9):1419-1428内部资料严禁翻印及传播与口服控缓释阿片类药物相比,多瑞吉?更具安全性WHO癌症三阶梯止痛指导原则(第二版)2002内部资料严禁翻印及传播多瑞吉?极少结合胃肠道μ受体,消化道不良显著低于口服强阿片药物内部资料严禁翻印及传播Meta分析显示:多瑞吉?便秘、呕心呕吐、头晕嗜睡明显少于口服控缓释吗啡Chinese Clinical Oncology.Feb.2008.Vo1.13.No.2通过中国12个临床研究的Meat分析,芬太尼透皮贴剂相比口服吗啡控释片,便秘发生率降低31%(P<0.00001),恶心呕吐发生率降低26%(P=0.0002),头痛嗜睡发生率降低10%(P=0.02).内部资料严禁翻印及传播多瑞吉?代谢产物无活性,长期使用安全性好1. Muijisers. Drugs, 2001; 61(51): 2289-23072. Charies E, et al. The Clinical Journal of Pain, 2002; 18: S3-S133. Gertrud A, et al. Journal of Pain Symptom Management, 2003; 25(1): 74-914. Mellar P. Dabis, MD. FOCP. MASCOO/ISOO 16th International Symposium, Supportive care in Cancer
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