ardrout of thesynthesis of thealiphatic squaramide图1.5 芳香族方酰胺的合成示意图及主产物(1)和异构体副产物(2、3)Scheme 1.5 the synthesis of thearomatic squaramides and the target product (1) and theisomer products (2,3)万方数据第一章绪论4OOClClNH2DMF8min0℃2h,20℃OONHNH70%OONHHN11%图1.6 方酰二氯与芳胺的反应Scheme 1.6 the reaction of squarate dichloride and aromaticamines OOEtOOEtOONHNHArArAr-NH2(2.1equiv)Zn(OTf)2toluene/DMF100℃1a-1hOOEtOOEtOONHOEtAr1Ar-NH2(1equiv)Zn(OTf)2toluene/DMF100℃(20mol%)Ar-NH2(1.1equiv)Zn(OTf)2EtOH,23℃(20mol%)OONHNHAr1Ar2图1.7 Zn(OTf)2催化合成对称或不对称取代芳香性方酰胺Scheme1.7Preparation of Symmetrically or unSymmetrically SubstitutedN,N–Diarylsquaramides byZn(OTf)2-Catalyzed Condensation1.2.2方酰胺的应用有关方酰胺应用的报道不胜枚举。以下主要列举了方酰胺在阴离子探针领域有代表性文献报道。Costa组首次报道方酰胺片段可以用于阴离子的识别[45](图1.8),他们合成的对称方酰胺化合物非常适合检测三羧酸根离子,ROESY和质谱实验证明离子确实是被受体所包围。万方数据
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