enfiltrationandcentrifugationforcancerdetection???????403.2.icalterationsdetectioncoupledwithMCE??????????..413.3Resultsanddiscussion?????????????????????????????????.413.3.1Comparisonbetweenfiltrationandcentrifugationforcancerdetection???????4233.parisonbetweenMCEandPAGE??????????????????443.3.icalterationsdetectioncoupledwithMCE??????????..463.3.4Repeatabilitytest???????????????????????????????????473.4Conclusions???????????.??.??..??????????????????????.47Chapter4Conclusions????????????????????????????????.49References??.??????????.???????????????????????????.50Appendix????????.?????.???????????????????????????.60Acknowledgements?????????.??..??????????????????????.61Achievementsinscientificresearch????????????????????????62Briefintroductionofauthorandsupervisor??????????????????.63VIII