502.[22]BODNARAG,QUELLETTEM,FROLKISM,etal.Extensionoflife-spanbyintroductionoftelomeraseintonormalhumancells[J].Science,1998,279:349~352.Researchadvancesincellularaging(Areview)HUANGDan(Dept.ofPathology,JNUMC,Guangzhou510632,China)[Abstract]Themechanismofcellularagingisstillnotquiteclear.Tosummarizeanumberofreports,itmainlyinvolvesthreecauses:(1)anismsmodification,thuscausingcellsenscence.(2)Thereareaseriesofgenesincellwhichdetermincellulargrowth,differentiation,aginganddeath(3)Criticaltelomereshortening.Celldividingmayleadtotelomereshortening.Oncethetelomereofcellshortentoacriticallengththatwillbringaboutcellsenescence.Telomerasecanlengthentelomereanddelaycellularaginganditsactivityisregulatedbymanyfactorsincludingsomeaginggenes.[Keywords]?cellularaging;?freeradicals;?clockgenes;?telomere
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